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Colakoglu, G. & Brown, A. (2009). Intermediate filaments exchange subunits along their length and elongate by end-to-end annealing. Journal of Cell Biology, 185:769-777 [PubMed] [pdf]
Chimeric filament formed by end-to-end annealing (0.43 MB) [view movie]
Chimeric filament formed by end-to-end annealing(0.36 MB) [view movie]
Circular filament formed by end-to-end annealing (0.43 MB) [view movie]
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Alami, N.H., Jung, P. & Brown, A. (2009). Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses. Journal of Neuroscience, 29:6625-6634 [PubMed] [pdf]
Movement of a neurofilament in a dilute lethal SCG neuron (0.47 MB) [view movie]
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Trivedi, N., Jung, P. & Brown (2007). Neurofilaments switch between distinct mobile and stationary states during their transport along axons. Journal of Neuroscience, 27:507-516 [PubMed] [pdf]
Pulse escape movie, 5 second intervals (11.5 MB) [view movie]
Pulse escape movie, 5 minute intervals (6.5 MB) [view movie]
Flash™ animation of fluorescence photobleaching strategy (0.15 MB) [view movie]
Flash™ animation of fluorescence photoactivation strategy (0.12 MB) [view movie]
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Brown, A., Wang, L. & Jung, P. (2005). Stochastic Simulation of Neurofilament Transport in Axons: The “Stop and Go” Hypothesis. Molecular Biology of the Cell, 16:4243-4255 [PubMed] [pdf]
Simulation of the movement of pulse of radiolabeled neurofilaments (0.7 MB)
[view movie]
Simulation of the movement of neurofilaments in mouse spinal motor axons (0.9 KB) [view movie]
Graphic representation of the simulated moving and pausing behavior of neurofilaments in mouse spinal motor axons (3.6 KB) [view movie]
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Yan, Y. & Brown, A. (2005). Neurofilament polymer transport in axons. Journal of Neuroscience 25:7014-7021 [PubMed] [pdf]
Capture of a neurofilament moving through a naturally occuring gap (4.0 MB)
[view movie]
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Uchida, A. & Brown, A. (2004). Arrival, reversal and departure of neurofilaments at the tips of growing axons. Molecular Biology of the Cell 15:4215-4225 [PubMed] [pdf]
Movement of a neurofilament into a growth cone (1.6 MB) [view movie]
Movement of a neurofilament into a growth cone (8.7 MB) [view movie]
Departure of a neurofilament from a growth cone (1.5 MB) [view movie]
Reversal of a neurofilament in a growth cone (3.1 MB) [view movie]
Reversal of a neurofilament in a growth cone (1.7 MB) [view movie]
Flash™ animation: hypothesis for neurofilament fate at axon tips (3.6 KB)
[view movie]
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Wang, L. & Brown, A. (2002). Rapid movement of microtubules in axons. Current Biology 12:1496-1501 [PubMed] [pdf]
Movement of a microtubule in a photobleached axon (2.8 MB) [view movie]
Movement of a microtubule in a photobleached axon (2.6 MB) [view movie]
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Wang, L. & Brown, A. (2001). Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching. Molecular Biology of the Cell 12:3257-3267 [PubMed] [pdf]
Shorter filament moving anterogradely (0.7 MB) [view movie]
Longer filament moving anterogradely (3.3 KB) [view movie]
Filament folding up on itself (3.1 MB) [view movie]
Punctate structure moving retrogradely (2.8 KB) [view movie]
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Wang, L., Ho, C.-L., Sun, D., Liem, R.K.H. & Brown, A. (2000). Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nature Cell Biology, 2:137-141 [PubMed] [pdf] [News and Views article]
Several filaments moving anterogradely (1.6 MB) [view movie]
Fast filament passing pausing filament (0.6 KB) [view movie] |
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